Funding by the National Lung and Blood Institute, Picture of a Child in a Hospital


The In-Hospital Trial results were published in the New England Journal of Medicine on January 24, 2017. Thank you to everyone who was involved. Click here to read the article

The Out of Hospital results were published in the New England Journal of Medicine in April 2015. Click here to read the publication

Listen to Dr. J. Michael Dean, co-investigator of the THAPCA Trials, speak about the Out of Hospital study results on The Scope Radio, a production of the University of Utah Health Sciences: Click here to listen

View recent press on the THAPCA study results.

Watch the video of one family’s decision to enroll their child into the THAPCA study. The Children and Clinical Studies Campaign is supported by the National Institutes of Health to increase understanding of research in kids and help families make informed decisions about participating in a pediatric study.

  Find the Children and Clinical Studies Campaign on Facebook


Picture of a heart being fixed.Cardiopulmonary arrest (when the heart stops beating) is a tragic event in children that is associated with high rates of death and long term disability. 

The Need

In children, this can occur in the hospital as a complication of many different medical conditions; cardiac arrest can also occur, suddenly, outside of the hospital as a result of an accident such as near drowning or a sudden illness.  There is a great need for better treatments for children resuscitated after cardiac arrest in each setting to improve ultimate quality of life and to prevent long term brain injury or death.

The National Heart, Lung, and Blood Institute (NHLBI) is funding the first large scale, multi-center study to help determine the best treatment for children who are successfully resuscitated after a cardiac arrest.

The Study

The study, entitled “Therapeutic Hypothermia after Pediatric Cardiac Arrest (THAPCA)”, will evaluate whether regulating the body temperature will improve the outcome for children after cardiac arrest. There is a separate study for children who arrest in the hospital (THAPCA-IH) and children who arrest out of the hospital (THAPCA-OH). The goal of these two trials is:

The THAPCA Trials investigative team has worked collaboratively since 2002 bringing together two federally funded pediatric clinical research networks to study this problem.  These two networks are the:



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